Bioinformatics Analyses of the Transcriptome Reveal Ube3a-Dependent Effects on Mitochondrial-Related Pathways

Bioinformatics Analyses of the Transcriptome Reveal Ube3a-Dependent Effects on Mitochondrial-Related Pathways

The <i>UBE3A</i> gene encodes the ubiquitin E3-ligase protein, UBE3A, which is implicated in severe neurodevelopmental disorders. Lack of UBE3A expression results in Angelman syndrome, while UBE3A overexpression, due to genomic 15q duplication, results in autism. The cellular roles of UB...

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Bibliographic Details
Main Authors: Julia Panov, Lilach Simchi, Yonatan Feuermann, Hanoch Kaphzan
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
Angelman syndrome
mitochondria
oxidative stress
reactive oxygen species
gene expression
machine learning
Online Access:https://www.mdpi.com/1422-0067/21/11/4156

Internet

https://www.mdpi.com/1422-0067/21/11/4156

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