Synthesis and late stage modifications of Cyl derivatives

Synthesis and late stage modifications of Cyl derivatives

A peptide Claisen rearrangement is used as key step to generate a tetrapeptide with a C-terminal double unsaturated side chain. Activation and cyclization give direct access to cyclopeptides related to naturally occurring histone deacetylase (HDAC) inhibitors Cyl-1 and Cyl-2. Late stage modification...

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Bibliographic Details
Main Authors: Phil Servatius, Uli Kazmaier
Format: Article
Language:English
Published: Beilstein-Institut 2022-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chelated enolate
claisen rearrangement
hdac inhibitor
peptide
late stage modification
Online Access:https://doi.org/10.3762/bjoc.18.19

Internet

https://doi.org/10.3762/bjoc.18.19

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