In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid

In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid

This study involved the development of innovative compounds consisting of dipeptide cross-links combined with hydroxamic acid. Our objective was to assess their binding affinities with histone deacetylase 8 (HDAC8) by conducting a docking study, comparing the results with the reference ligand, sube...

Full description

Bibliographic Details
Main Authors:	omer mohammed ammash, Shakir M. Alwan, Ali R.M. albakaa, İsmail Alshrif Ibrheam ben Sulaiman
Format:	Article
Language:	English
Published:	College of Pharmacy / Mustansiriyah University 2024-04-01
Series:	Al-Mustansiriyah Journal of Pharmaceutical Sciences
Subjects:	Dipeptide cross-links Hydroxamic acid Histone deacetylase 8 (HDAC8) Binding affinities Docking study Physicochemical properties
Online Access:	https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1059

Similar Items

Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases
by: Anton Frühauf, et al.
Published: (2021-08-01)

Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid Malignancies
by: Marinella Zilli, et al.
Published: (2013-07-01)

A Novel Hydroxamic Acid-Based Curcumin Derivative as Potent Histone Deacetylase Inhibitor for the Treatment of Glioblastoma
by: Hao Wang, et al.
Published: (2021-11-01)

Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis
by: Ehab Ghazy, et al.
Published: (2022-01-01)

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity
by: Salma Darwish, et al.
Published: (2022-07-01)

Thiết kế, tổng hợp và đánh giá khả năng ức chế enzyme histone deacetylase (HDAC) in silico của một số dẫn xuất tương tự belinostat
by: Nguyễn Cường Quốc, et al.
Published: (2020-06-01)

In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model
by: Thiemann Markus, et al.
Published: (2012-03-01)

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer
by: Ana Vuletić, et al.
Published: (2023-12-01)

Hydroxamic acid - A novel molecule for anticancer therapy
by: Dilipkumar Pal, et al.
Published: (2012-01-01)

Histone deacetylases and their inhibitors: molecular mechanisms and therapeutic implications in diabetes mellitus
by: Xiaojie Wang, et al.
Published: (2012-08-01)

Histone deacetylase inhibition by suberoylanilide hydroxamic acid during reperfusion promotes multifaceted brain and vascular protection in spontaneously hypertensive rats with transient ischaemic stroke
by: Andrea Díaz-Pérez, et al.
Published: (2024-03-01)

Design, synthesis and biological evaluation of novel histone deacetylase inhibitors based on virtual screening
by: Hui Lu, et al.
Published: (2011-12-01)

Effects and related mechanisms of histone deacetylase inhibitors on the proliferation of choroidal melanoma C918 cell line
by: Yi-Meng Zhang, et al.
Published: (2023-02-01)

A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors
by: Anna Fontana, et al.
Published: (2022-09-01)

HDAC3 and HDAC8 are required for cilia assembly and elongation
by: Seon-ah Park, et al.
Published: (2019-08-01)

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
by: Giorgio Milazzo, et al.
Published: (2020-05-01)

Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities
by: Jung-Chun Chu, et al.
Published: (2023-12-01)

Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis
by: Hanxi Zheng, et al.
Published: (2023-01-01)

Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase
by: Joonhyeok Choi, et al.
Published: (2022-01-01)

Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer
by: Nikolaos Garmpis, et al.
Published: (2022-10-01)

Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy
by: Richard S. Laschanzky, et al.
Published: (2019-09-01)

Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity against Leukemias and Lymphomas of Novel, Tricyclic Vorinostat Analogues
by: Bartosz Bieszczad, et al.
Published: (2021-08-01)

Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target
by: Hanxi Zheng, et al.
Published: (2023-01-01)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
by: Masumeh Sanaei, et al.
Published: (2019-01-01)

Histone deacetylases modulate resistance to the therapy in lung cancer
by: Estefanía Contreras-Sanzón, et al.
Published: (2022-10-01)

Hydroxamate-Based Histone Deacetylase Inhibitors as Potential Mediators to Induce Dentine Regeneration by Human Dental Pulp Cell
by: Indrani Sulistyowati, et al.
Published: (2021-10-01)

Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities
by: Feifei Yang, et al.
Published: (2019-07-01)

Histone Deacetylase Inhibitors in the Treatment of Hepatocellular Carcinoma: Current Evidence and Future Opportunities
by: Nikolaos Garmpis, et al.
Published: (2021-03-01)

Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression
by: Hyun-Sun Park, et al.
Published: (2021-05-01)

The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors
by: Duong Tien Anh, et al.
Published: (2023-02-01)

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors
by: Delcuve Geneviève P, et al.
Published: (2012-03-01)

The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancer
by: Dineo eKhabele
Published: (2014-05-01)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
by: Monica Phimmachanh, et al.
Published: (2020-10-01)

Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies
by: Gunasingham Parthiban, et al.
Published: (2022-11-01)

Vorinostat (SAHA) and Breast Cancer: An Overview
by: Anna Wawruszak, et al.
Published: (2021-09-01)

Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells
by: Jakub Ptacek, et al.
Published: (2023-03-01)

Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer
by: Siddhartha Das Pramanik, et al.
Published: (2022-08-01)

Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention
by: Dusan Ruzic, et al.
Published: (2022-01-01)

Advanced Progress of Histone Deacetylases in Rheumatic Diseases
by: Liu XM, et al.
Published: (2024-02-01)

Histone Deacetylase Inhibitor SAHA Improves High Salinity Tolerance Associated with Hyperacetylation-Enhancing Expression of Ion Homeostasis-Related Genes in Cotton
by: Shibin He, et al.
Published: (2020-09-01)