Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes

Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes

Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D) onset; however, the precise nature of their contribution to disease remains poorly defined. To examine how NETs affect immune functions in T1D, we investigated NET composition and their...

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Bibliographic Details
Main Authors: Zuzana Parackova, Irena Zentsova, Petra Vrabcova, Adam Klocperk, Zdenek Sumnik, Stepanka Pruhova, Lenka Petruzelkova, Robert Hasler, Anna Sediva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
NET
netosis
type 1 diabetes
monocyte-derived dendritic cells
innate immunity
autoimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00661/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00661/full

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