Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation

Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation

Calcium ion movements between cellular stores and the cytosol govern muscle contraction, the most energy-consuming function in mammals, which confers skeletal myofibers a pivotal role in glycemia regulation. Chronic myoplasmic calcium elevation (“calcium stress”), found in malignant hyperthermia-sus...

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Bibliographic Details
Main Authors: Eshwar R Tammineni, Lourdes Figueroa, Carlo Manno, Disha Varma, Natalia Kraeva, Carlos A Ibarra, Amira Klip, Sheila Riazi, Eduardo Rios
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
transcription factors
phosphorylation
protein kinase
glucose transport
immunocytochemistry
Online Access:https://elifesciences.org/articles/78874

Internet

https://elifesciences.org/articles/78874

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