Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Introduction: Fusion of the fragment crystallizable (Fc) to protein therapeutics is commonly used to extend the circulation time by enhancing neonatal Fc-receptor (FcRn)-mediated endosomal recycling and slowing renal clearance. This study applied kinetic modeling to gain insights into the cellular p...

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Bibliographic Details
Main Authors: Heechun Kwak, Min-Soo Kim, Suyong Kim, Jiyoung Kim, Yasunori Aoki, Suk-Jae Chung, Hyun-Ja Nam, Wooin Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
ADAMTS13
kinetic modeling
pharmacokinetics
Fc-fusion
recombinant proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1352842/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1352842/full

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