Folate intake, alcohol consumption, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism: influence on prostate cancer risk and interactions

Folate intake, alcohol consumption, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism: influence on prostate cancer risk and interactions

Purpose: Folate is essential to DNA methylation and synthesis and may have a complex dualistic role in prostate cancer. Alcohol use may increase risk and epigenetic factors may interact with lifestyle exposures. We aimed to characterize the independent and joint effects of folate intake, alcohol con...

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Bibliographic Details
Main Authors: Lindsay C Kobayashi, Heather eLimburg, Qun eMiao, Christy eWoolcott, Leanne L Bedard, Thomas E Massey, Kristan J Aronson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Oncology
Subjects:
Men
genetic variants
alcohol
prostate cancer
gene-environment interactions
Carbon Metabolism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00100/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00100/full

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