Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters

Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters

Abstract Background A wide range of bioactive compounds is produced by enzymes and enzymatic complexes encoded in biosynthetic gene clusters (BGCs). These BGCs can be identified and functionally annotated based on their DNA sequence. Candidates for further research and development may be prioritized...

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Bibliographic Details
Main Authors: Snorre Sulheim, Fredrik A. Fossheim, Alexander Wentzel, Eivind Almaas
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Bioinformatics
Subjects:
Biosynthetic gene clusters
Genome-scale metabolic model
AntiSMASH
Polyketide synthases
Natural products
Heterologous expression
Online Access:https://doi.org/10.1186/s12859-021-03985-0

Internet

https://doi.org/10.1186/s12859-021-03985-0

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