MEK1/2 Inhibition Synergistically Enhances the Preventive Effects of Normobaric Oxygen on Spinal Cord Injury in Decompression Sickness Rats

MEK1/2 Inhibition Synergistically Enhances the Preventive Effects of Normobaric Oxygen on Spinal Cord Injury in Decompression Sickness Rats

A previous study from our team found that hyperbaric oxygen (HBO) pretreatment attenuated decompression sickness (DCS) spinal cord injury by upregulating heat shock protein 32 (HSP32) via the ROS/p38 MAPK pathway. Meanwhile, a MEK1/2-negative regulatory pathway was also activated to inhibit HSP32 ov...

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Bibliographic Details
Main Authors: Quan Zhou, Xiangyang Meng, Guoyang Huang, Hongjie Yi, Juan Zheng, Kun Zhang, Weigang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
decompression sickness
spinal cord injury
normobaric oxygen
MEK1/2
U0126
heat shock protein 32
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.674430/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.674430/full

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