Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists

The opioid pharmacological profile of cis-(−)-N-normetazocine derivatives is deeply affected by the nature of their N-substituents. Here, our efforts were focused on the synthesis and pharmacological evaluation of novel derivatives of the lead LP1, a multitarget opioid analgesic compound featuring a...

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Bibliographic Details
Main Authors: Rita Turnaturi, Carmela Parenti, Orazio Prezzavento, Agostino Marrazzo, Paschalina Pallaki, Zafiroula Georgoussi, Emanuele Amata, Lorella Pasquinucci
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
6,7-benzomorphan derivatives
MOR agonist
pain
radioligand competitive binding
cAMP accumulation assay
tail-flick test
Online Access:http://www.mdpi.com/1420-3049/23/3/677

Internet

http://www.mdpi.com/1420-3049/23/3/677

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