Endogenous CCL21-Ser deficiency reduces B16–F10 melanoma growth by enhanced antitumor immunity

Endogenous CCL21-Ser deficiency reduces B16–F10 melanoma growth by enhanced antitumor immunity

The chemokine CCL21 regulates immune and cancer cell migration through its receptor CCR7. The Ccl21a gene encodes the isoform CCL21-Ser, predominantly expressed in the thymic medulla and the secondary lymphoid tissues. This study examined the roles of CCL21-Ser in the antitumor immune response in Cc...

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Bibliographic Details
Main Authors: Ryonosuke Fujie, Kaoru Kurowarabe, Yuki Yamada, Kakeru Fujiwara, Hayato Nakatani, Kenta Tsutsumi, Ryota Hayashi, Hinami Kawahata, Megumi Miyamoto, Madoka Ozawa, Tomoya Katakai, Yousuke Takahama, Izumi Ohigashi, Haruko Hayasaka
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
Melanoma
Chemokine
Lymph node
CD8
Treg
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402306423X

Internet

http://www.sciencedirect.com/science/article/pii/S240584402306423X

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