Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells

Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells

Abstract Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant cell lines were determined using the MTT assay. Effects of Shikonin derivatives on BCRP, MDR1 and MRP transcript and protein levels...

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Bibliographic Details
Main Authors: Seyed Abbas Mirzaei, Somayeh Reiisi, Parmida Ghiasi Tabari, Abolfazl Shekari, Fatemeh Aliakbari, Elaheh Azadfallah, Fatemeh Elahian
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-21710-5

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https://doi.org/10.1038/s41598-018-21710-5

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