Immunity to Sda1 Protects against Infection by Sda1<sup>+</sup> and Sda1<sup>−</sup> Serotypes of Group A <i>Streptococcus</i>

Immunity to Sda1 Protects against Infection by Sda1<sup>+</sup> and Sda1<sup>−</sup> Serotypes of Group A <i>Streptococcus</i>

Group A <i>Streptococcus</i> (GAS) causes a variety of diseases globally. The DNases in GAS promote GAS evasion of neutrophil killing by degrading neutrophil extracellular traps (NETs). Sda1 is a prophage-encoded DNase associated with virulent GAS strains. However, protective immunity ag...

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Bibliographic Details
Main Authors: Shuai Bi, Jie Wang, Meiyi Xu, Ning Li, Beinan Wang
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Vaccines
Subjects:
group A <i>streptococcus</i>
DNases
Sda1
neutrophil extracellular traps
pharyngeal colonization
Online Access:https://www.mdpi.com/2076-393X/10/1/102

Internet

https://www.mdpi.com/2076-393X/10/1/102

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