Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer

Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer

Glycosylation patterns commonly change in cancer, resulting in expression of tumor-associated carbohydrate antigens (TACA). While promising, currently available anti-glycan antibodies are not useful for clinical cancer therapy. Here, we show that potent anti-glycan antibodies can be engineered to ac...

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Bibliographic Details
Main Authors: Ron Amon, Ronit Rosenfeld, Shahar Perlmutter, Oliver C. Grant, Sharon Yehuda, Aliza Borenstein-Katz, Ron Alcalay, Tal Marshanski, Hai Yu, Ron Diskin, Robert J. Woods, Xi Chen, Vered Padler-Karavani
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
cancer
tumor
glycosylation
antibodies
carbohydrate
polymer
Online Access:https://www.mdpi.com/2072-6694/12/10/2824

Internet

https://www.mdpi.com/2072-6694/12/10/2824

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