SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination

SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination

Summary: We here demonstrate that SERTAD1 is an adaptor protein responsible for the regulation of lysine 63 (K63)-linked NLRP3 polyubiquitination by the Cullin1 E3 ubiquitin ligase upon inflammasome activation. SERTAD1 specifically binds to NLRP3 but not to other inflammasome sensors. This endogenou...

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Bibliographic Details
Main Authors: Jihoon Ha, Minbeom Kim, Jin Seok Park, Yerin Lee, Jae Young Lee, Jin-Cheol Shin, Dongyeob Seo, Seong Shil Park, Jiyeon You, Su Myung Jung, Hye Young Kim, Seiya Mizuno, Satoru Takahashi, Seong-Jin Kim, Seok Hee Park
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000809

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http://www.sciencedirect.com/science/article/pii/S2211124724000809

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