Impact of Short-Term (+)-JQ1 Exposure on Mouse Aorta: Unanticipated Inhibition of Smooth Muscle Contractility

Impact of Short-Term (+)-JQ1 Exposure on Mouse Aorta: Unanticipated Inhibition of Smooth Muscle Contractility

(+)-JQ1, a specific chemical inhibitor of bromodomain and extraterminal (BET) family protein 4 (BRD4), has been reported to inhibit smooth muscle cell (SMC) proliferation and mouse neointima formation via BRD4 regulation and modulate endothelial nitric oxide synthase (eNOS) activity. This study aime...

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Bibliographic Details
Main Authors: Binjie Yan, Yu Gui, Yanan Guo, Jiaxing Sun, Mahmoud Saifeddine, Jingti Deng, Joseph A. Hill, Morley D. Hollenberg, Zhi-Sheng Jiang, Xi-Long Zheng
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
(+)-JQ1
smooth muscle cell
eNOS
contractility
calcium
Online Access:https://www.mdpi.com/2073-4409/12/11/1461

Internet

https://www.mdpi.com/2073-4409/12/11/1461

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