Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer

Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer

Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and hypovascularization, resulting in significant intratumoral hypoxia (low oxygen) that contributes to its aggressiveness, therapeutic resistance, and high mortality. Despite oxygen being a fundamental requireme...

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Bibliographic Details
Main Authors: Kate E.R. Hollinshead, Seth J. Parker, Vinay V. Eapen, Joel Encarnacion-Rosado, Albert Sohn, Tugba Oncu, Michael Cammer, Joseph D. Mancias, Alec C. Kimmelman
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
hypoxia
pancreatic cancer
respiration
electron transport chain
aspartate
supercomplexes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312201

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http://www.sciencedirect.com/science/article/pii/S2211124720312201

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