Depletion of Toll-Like Receptor-9 Attenuates Renal Tubulointerstitial Fibrosis After Ischemia-Reperfusion Injury

Depletion of Toll-Like Receptor-9 Attenuates Renal Tubulointerstitial Fibrosis After Ischemia-Reperfusion Injury

Toll-like receptor-9 (TLR-9) is a potent proinflammatory receptor that mediates renal injury. However, the reported effects of TLR-9 are contradictory. Here, using a traditional mouse AKI→CKD transition model, the roles of TLR-9 during the transition from acute kidney injury (AKI) to chronic kidney...

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Bibliographic Details
Main Authors: Haofeng Zheng, Yannan Zhang, Lei Li, Rui Zhang, Zihuan Luo, Zhe Yang, Yongrong Ye, Jiannan He, Qiquan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TLR-9
acute kidney injury
chronic kidney disease
fibrosis
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.641527/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.641527/full

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