Targeting Oxidative Stress: Novel Coumarin-Based Inverse Agonists of GPR55

Targeting Oxidative Stress: Novel Coumarin-Based Inverse Agonists of GPR55

Oxidative stress is associated with different neurological and psychiatric diseases. Therefore, development of new pharmaceuticals targeting oxidative dysregulation might be a promising approach to treat these diseases. The G-protein coupled receptor 55 (GPR55) is broadly expressed in central nervou...

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Bibliographic Details
Main Authors: Matthias Apweiler, Soraya Wilke Saliba, Jana Streyczek, Thomas Hurrle, Simone Gräßle, Stefan Bräse, Bernd L. Fiebich
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
GPR55
coumarin-based compounds
ROS
inverse agonism
8-Iso-PGF<sub>2α</sub>
Online Access:https://www.mdpi.com/1422-0067/22/21/11665

Internet

https://www.mdpi.com/1422-0067/22/21/11665

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