The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction

The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction

Here, we investigated the role of the canonical Wnt signaling pathway transcriptional regulators at the neuromuscular junction. Upon applying a denervation paradigm, the transcription levels of Ctnnb1, Tcf7l1, Tle1, Tle2, Tle3, and Tle4 were significantly downregulated. A significant decrease in can...

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Bibliographic Details
Main Authors: Lea Gessler, Danyil Huraskin, Nane Eiber, Said Hashemolhosseini
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
β-catenin
Axin2
TLE3
TLE4
synaptic gene expression
neuromuscular junction
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1360368/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2024.1360368/full

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