Culture conditions greatly impact the levels of vesicular and extravesicular Ago2 and RNA in extracellular vesicle preparations

Culture conditions greatly impact the levels of vesicular and extravesicular Ago2 and RNA in extracellular vesicle preparations

Abstract Extracellular vesicle (EV)‐carried miRNAs can influence gene expression and functional phenotypes in recipient cells. Argonaute 2 (Ago2) is a key miRNA‐binding protein that has been identified in EVs and could influence RNA silencing. However, Ago2 is in a non‐vesicular form in serum and ca...

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Bibliographic Details
Main Authors: Lizandra Jimenez, Bahnisikha Barman, Youn Jae Jung, Lauren Cocozza, Evan Krystofiak, Cherie Saffold, Kasey C. Vickers, John T. Wilson, T. Renee Dawson, Alissa M. Weaver
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Journal of Extracellular Vesicles
Subjects:
argonaute 2
extracellular RNA
extracellular vesicles
RNA‐binding proteins
serum
Online Access:https://doi.org/10.1002/jev2.12366

Internet

https://doi.org/10.1002/jev2.12366

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