Diabetes-Induced Amplification of Nociceptive DRG Neuron Output by Upregulation of Somatic T-Type Ca<sup>2+</sup> Channels

Diabetes-Induced Amplification of Nociceptive DRG Neuron Output by Upregulation of Somatic T-Type Ca<sup>2+</sup> Channels

The development of pain symptoms in peripheral diabetic neuropathy (PDN) is associated with the upregulation of T-type Ca<sup>2+</sup> channels (T-channels) in the soma of nociceptive DRG neurons. Moreover, a block of these channels in DRG neurons effectively reversed mechanical and ther...

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Bibliographic Details
Main Authors: Arsentii Ivasiuk, Maksym Matvieienko, Nikolai I. Kononenko, Dmytro E. Duzhyy, Sergiy M. Korogod, Nana Voitenko, Pavel Belan
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomolecules
Subjects:
calcium current
diabetic painful neuropathy
action potential
spinal cord
nociception
temperature dependence
Online Access:https://www.mdpi.com/2218-273X/13/9/1320

Internet

https://www.mdpi.com/2218-273X/13/9/1320

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