Ketamine’s acute effects on negative brain states are mediated through distinct altered states of consciousness in humans

Abstract Ketamine commonly and rapidly induces dissociative and other altered states of consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these experiences remain unknown. We used functional neuroimaging to engage key regions of the brain’s affective circuits during a...

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Bibliographic Details
Main Authors: Laura M. Hack, Xue Zhang, Boris D. Heifets, Trisha Suppes, Peter J. van Roessel, Jerome A. Yesavage, Nancy J. Gray, Rachel Hilton, Claire Bertrand, Carolyn I. Rodriguez, Karl Deisseroth, Brian Knutson, Leanne M. Williams
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42141-5