PCSK9 Induces Tissue Factor Expression by Activation of TLR4/NFkB Signaling

PCSK9 Induces Tissue Factor Expression by Activation of TLR4/NFkB Signaling

Proprotein convertase subtilisin kexin 9 (PCSK9) increases LDL cholesterol (C) concentration by accelerating the hepatic degradation of the LDL receptor (R) thus promoting atherogenesis. The molecule, however, also exerts proinflammatory effects independent of circulating LDL-C by enhancing local cy...

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Bibliographic Details
Main Authors: Valentina Scalise, Chiara Sanguinetti, Tommaso Neri, Silvana Cianchetti, Michele Lai, Vittoria Carnicelli, Alessandro Celi, Roberto Pedrinelli
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
PCSK9
tissue factor
TLR4
NFkB
inflammation
quantitative confocal microscopy
Online Access:https://www.mdpi.com/1422-0067/22/23/12640

Internet

https://www.mdpi.com/1422-0067/22/23/12640

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