Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome driven pyroptotic cell death. We recently reported that the danger-associated molecular pattern (DAMP) oxidized mitochondrial DNA (ox-mtDNA)...

Full description

Bibliographic Details
Main Authors: Grace A. Ward, Robert P. Dalton, Benjamin S. Meyer, Amy F. McLemore, Amy L. Aldrich, Nghi B. Lam, Alexis H. Onimus, Nicole D. Vincelette, Thu Le Trinh, Xianghong Chen, Alexandra R. Calescibetta, Sean M. Christiansen, Hsin-An Hou, Joseph O. Johnson, Kenneth L. Wright, Eric Padron, Erika A. Eksioglu, Alan F. List
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
oxidized mitochondrial DNA
DAMP
Myelodysplastic Syndromes
inflammasome
pyroptosis
Toll-like receptor
Online Access:https://www.mdpi.com/1422-0067/24/4/3896

Internet

https://www.mdpi.com/1422-0067/24/4/3896

Similar Items