Coordinated activation of DNMT3a and TET2 in cancer stem cell-like cells initiates and sustains drug resistance in hepatocellular carcinoma

Coordinated activation of DNMT3a and TET2 in cancer stem cell-like cells initiates and sustains drug resistance in hepatocellular carcinoma

Abstract Background Resistance to targeted therapies represents a significant hurdle to successfully treating hepatocellular carcinoma (HCC). While epigenetic abnormalities are critical determinants of HCC relapse and therapeutic resistance, the underlying mechanisms are poorly understood. We aimed...

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Bibliographic Details
Main Authors: Tao Cheng, Changli Zhou, Sicheng Bian, Kelsey Sobeck, Yahui Liu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
Sorafenib
Epigenetics
Drug resistance
DNA methyltransferases
The ten-eleven translocation proteins
Online Access:https://doi.org/10.1186/s12935-024-03288-3

Internet

https://doi.org/10.1186/s12935-024-03288-3

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