Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway

Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway

Cerebral ischemia is a major cause of brain dysfunction, neuroinflammation and oxidative stress have been implicated in the pathophysiological process of cerebral ischemia/reperfusion injury. Celastrol is a potent inhibitor of inflammation and oxidative stress that has little toxicity. The present s...

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Bibliographic Details
Main Authors: Bo Zhang, Qi Zhong, Xuhui Chen, Xi Wu, Rong Sha, Guizhi Song, Chuanhan Zhang, Xiangdong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
celastrol
neuroinflammation
oxidative stress
neurological deficit
cerebral ischemia reperfusion
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00847/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00847/full

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