Antigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization

Antigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization

Staphylococcus aureus carries an exceptional repertoire of virulence factors that aid in immune evasion. Previous single-target approaches for S. aureus-specific vaccines and monoclonal antibodies (mAbs) have failed in clinical trials due to the multitude of virulence factors released during infecti...

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Bibliographic Details
Main Authors: Shweta Kailasan, Ravi Kant, Madeleine Noonan-Shueh, Tulasikumari Kanipakala, Grant Liao, Sergey Shulenin, Daisy W. Leung, Richard A. Alm, Rajan P. Adhikari, Gaya K. Amarasinghe, Michael L. Gross, M. Javad Aman
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
Α-hemolysin
leukocidin
epitope mapping
hydrogen/deuterium exchange mass spectrometry
pneumonia
Staphylococcus aureus
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2083467

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https://www.tandfonline.com/doi/10.1080/19420862.2022.2083467

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