Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth

Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth

Abstract Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as the disease only becomes symptomatic at an advanced stage. Growing evidence suggests that histone deacetylases (HDACs), a group of epigenetic enzymes overexpressed in precancerous lesions of CRC, may r...

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Bibliographic Details
Main Authors: Namin Duan, Xiaohui Hu, Huiran Qiu, Rui Zhou, Yuru Li, Wenxia Lu, Yamin Zhu, Shuang Shen, Wenhui Wu, Feifei Yang, Ning Liu
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06205-0

Internet

https://doi.org/10.1038/s41419-023-06205-0

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