A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells. Two main distinct developmental states of ESCs have been stabilized in vitro, a naïve pre-implantation stage and a primed post-implantation stage. Based on two recently...

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Bibliographic Details
Main Authors: Damien Detraux, Marino Caruso, Louise Feller, Maude Fransolet, Sébastien Meurant, Julie Mathieu, Thierry Arnould, Patricia Renard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
2C-like cells
naive-to-primed
metabolism
succinate
heme
Online Access:https://elifesciences.org/articles/78546

Internet

https://elifesciences.org/articles/78546

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