Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum. However, their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct target. In addition, the hearing damage caused by aminoglycosides in...

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Bibliographic Details
Main Authors: Jia Fang, Zhuangzhuang Li, Pengjun Wang, Xiaoxu Zhang, Song Mao, Yini Li, Dongzhen Yu, Xiaoyan Li, Yazhi Xing, Haibo Shi, Shankai Yin
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-10-01
Series:Neural Regeneration Research
Subjects:
degeneration
hearing loss
macrophages
mcc950
neuroinflammation
nlrp3 inflammasome
ototoxicity
pyroptosis
sensorineural hearing loss
spiral ganglion neuron
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01879

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https://journals.lww.com/10.4103/NRR.NRR-D-23-01879

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