Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)

Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)

Abstract Background Coenzyme A (CoA) is a carrier of acyl groups. This cofactor is synthesized from pantothenic acid in five steps. The phosphorylation of pantothenate is catalyzed by pantothenate kinase (CoaA), which is a key step in the CoA biosynthetic pathway. To determine whether the enhancemen...

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Bibliographic Details
Main Authors: Hirotaka Kudo, Sho Ono, Kenta Abe, Mami Matsuda, Tomohisa Hasunuma, Tomoyasu Nishizawa, Munehiko Asayama, Hirofumi Nishihara, Shigeru Chohnan
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Microbial Cell Factories
Subjects:
Coenzyme A
Acetyl-CoA
Pantothenate kinase
Poly(3-hydroxybutyrate)
Escherichia coli
Pantothenic acid
Online Access:https://doi.org/10.1186/s12934-023-02083-5

Internet

https://doi.org/10.1186/s12934-023-02083-5

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