Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization

Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization

IntroductionOligoasthenoteratozoospermia (OAT) is a major cause of infertility in males. Only a few pathogenic genes of OAT have been clearly identified till now. A large number of OAT-affected cases remain largely unknown.MethodsHere, Whole-exome sequencing (WES) in 725 idiopathic OAT patients was...

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Bibliographic Details
Main Authors: Haowei Bai, Yanwei Sha, Yueqiu Tan, Peng Li, Yuxiang Zhang, Junwei Xu, Shuai Xu, Zhiyong Ji, Xiaobo Wang, Wei Chen, Jianxiong Zhang, Chencheng Yao, Zheng Li, Erlei Zhi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Endocrinology
Subjects:
TAF7L
hemizygous variant
oligoasthenoteratozoospermia
ICSI
male infertility
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1099270/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.1099270/full

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