Design, Synthesis, and Biological Evaluation of Pyrano[2,3-c]-pyrazole–Based RalA Inhibitors Against Hepatocellular Carcinoma

Design, Synthesis, and Biological Evaluation of Pyrano[2,3-c]-pyrazole–Based RalA Inhibitors Against Hepatocellular Carcinoma

The activation of Ras small GTPases, including RalA and RalB, plays an important role in carcinogenesis, tumor progress, and metastasis. In the current study, we report the discovery of a series of 6-sulfonylamide-pyrano [2,3-c]-pyrazole derivatives as novel RalA inhibitors. ELISA-based biochemical...

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Bibliographic Details
Main Authors: Yuting Wang, Mingyao He, Xiang Li, Jinlong Chai, Qinglin Jiang, Cheng Peng, Gu He, Wei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Chemistry
Subjects:
RalA inhibitors
pyrano[2;3-c]-pyrazole
hepatocellular carcinoma
synthesis
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.700956/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.700956/full

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