Aurintricarboxylic Acid Decreases RNA Toxicity in a <i>C. elegans</i> Model of Repeat Expansions

Aurintricarboxylic Acid Decreases RNA Toxicity in a <i>C. elegans</i> Model of Repeat Expansions

Pathologic expansions of DNA nucleotide tandem repeats may generate toxic RNA that triggers disease phenotypes. RNA toxicity is the hallmark of multiple expansion repeat disorders, including myotonic dystrophy type 1 (DM1). To date, there are no available disease-modifying therapies for DM1. Our aim...

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Bibliographic Details
Main Authors: Maya Braun, Shachar Shoshani, Anna Mellul-Shtern, Yuval Tabach
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Toxins
Subjects:
CUG repeats
RNA interference
drug repositioning
<i>C. elegans</i>
small RNA pathway
Online Access:https://www.mdpi.com/2072-6651/13/12/910

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https://www.mdpi.com/2072-6651/13/12/910

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