Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice

Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice

The analysis of blood samples from mice treated with the PDE4 inhibitor Roflumilast revealed an unexpected reduction in serum potassium levels, while sodium and chloride levels were unaffected. Treatment with several structurally distinct PAN-PDE4 inhibitors, including Roflumilast, Rolipram, RS25344...

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Bibliographic Details
Main Authors: Abigail Boyd, Peter Lochmaier, Daniel Irelan, Edward Fiedler, Ji Young Lee, Brian Fouty, Lina Abou Saleh, Wito Richter
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biology
Subjects:
cAMP-phosphodiesterase
PDE4
serum potassium
adrenergic signaling
hypokalemia
Online Access:https://www.mdpi.com/2079-7737/11/11/1582

Internet

https://www.mdpi.com/2079-7737/11/11/1582

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