Stochastic principles governing alternative splicing of RNA.

The dominance of the major transcript isoform relative to other isoforms from the same gene generated by alternative splicing (AS) is essential to the maintenance of normal cellular physiology. However, the underlying principles that determine such dominance remain unknown. Here, we analyzed the phy...

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Bibliographic Details
Main Authors: Jianfei Hu, Eli Boritz, William Wylie, Daniel C Douek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5614656?pdf=render