Immunogenicity in African Green Monkeys of M Protein Mutant Vesicular Stomatitis Virus Vectors and Contribution of Vector-Encoded Flagellin

Immunogenicity in African Green Monkeys of M Protein Mutant Vesicular Stomatitis Virus Vectors and Contribution of Vector-Encoded Flagellin

Recombinant vesicular stomatitis virus (VSV) is a promising platform for vaccine development. M51R VSV, an attenuated, M protein mutant strain, is an effective inducer of Type I interferon and dendritic cell (DC) maturation, which are desirable properties to exploit for vaccine design. We have previ...

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Bibliographic Details
Main Authors: Marlena M. Westcott, Jason Smedberg, Matthew J. Jorgensen, Shelby Puckett, Douglas S. Lyles
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Vaccines
Subjects:
vesicular stomatitis virus
vaccine
vector
flagellin
nonhuman primate
African green monkey
Online Access:http://www.mdpi.com/2076-393X/6/1/16

Internet

http://www.mdpi.com/2076-393X/6/1/16

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