Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis

Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis

Aims: Vascular senescence, which is closely related to epigenetic regulation, is an early pathological condition in cardiovascular diseases including atherosclerosis. Inhibition of S-adenosylhomocysteine hydrolase (SAHH) and the consequent increase of S-adenosylhomocysteine (SAH), a potent inhibitor...

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Bibliographic Details
Main Authors: Yiran You, Xu Chen, Yu Chen, Juan Pang, Qian Chen, Qiannan Liu, Hongliang Xue, Yupeng Zeng, Jinghe Xiao, Jiaxin Mi, Yi Tang, Wenhua Ling
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Redox Biology
Subjects:
vascular senescence
Atherosclerosis
S-adenosylhomocysteine hydrolase
DNA methylation
mitochondrial dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172300229X

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http://www.sciencedirect.com/science/article/pii/S221323172300229X

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