(1<i>R</i>,2<i>R</i>,3<i>S</i>,4<i>R</i>)-1-(Acetylamino)-2,4,5-tris(acetyloxy)-1-((2<i>S</i>)-4-(benzyloxy)-5-oxo-2,5-dihydrofuran-2-yl)pentan-3-yl Acetate

(1<i>R</i>,2<i>R</i>,3<i>S</i>,4<i>R</i>)-1-(Acetylamino)-2,4,5-tris(acetyloxy)-1-((2<i>S</i>)-4-(benzyloxy)-5-oxo-2,5-dihydrofuran-2-yl)pentan-3-yl Acetate

Treatment of <i>N</i>-acetylneuraminic acid with excess base in the presence of benzyl bromide gives a polyhydroxylated 1,4 lactone which after acetylation gave the title compound in 20% overall yield. The structure of the product was confirmed by single crystal X-ray diffraction analysi...

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Bibliographic Details
Main Authors: Liam S. Fitzgerald, Ciaran O’Malley, Paul V. Murphy
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molbank
Subjects:
sialic acid
N-acetylneuraminic acid
1,4 lactones
γ-lactones
polyhydroxylated compounds
Online Access:https://www.mdpi.com/1422-8599/2022/1/M1337

Internet

https://www.mdpi.com/1422-8599/2022/1/M1337

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