Targeting Insulin Receptor with a Novel Internalizing Aptamer

Targeting Insulin Receptor with a Novel Internalizing Aptamer

Nucleic acid-based aptamers are emerging as therapeutic antagonists of disease-associated proteins such as receptor tyrosine kinases. They are selected by an in vitro combinatorial chemistry approach, named Systematic Evolution of Ligands by Exponential enrichment (SELEX), and thanks to their small...

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Bibliographic Details
Main Authors: Margherita Iaboni, Raffaela Fontanella, Anna Rienzo, Maria Capuozzo, Silvia Nuzzo, Gianluca Santamaria, Silvia Catuogno, Gerolama Condorelli, Vittorio de Franciscis, Carla Lucia Esposito
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer
cancer therapy
IGF-1R
IR
SELEX
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300914

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http://www.sciencedirect.com/science/article/pii/S2162253117300914

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