Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs

Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs

Maternal obesity has deleterious effects on the process of establishing oocyte DNA methylation; yet the underlying mechanisms remain unclear. Here, we found that maternal obesity disrupted the genomic methylation of oocytes using a high-fat diet (HFD) induced mouse model, at least a part of which wa...

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Bibliographic Details
Main Authors: Shuo Chao, Jun Lu, Li-Jun Li, Hong-Yan Guo, Kuipeng Xu, Ning Wang, Shu-Xian Zhao, Xiao-Wen Jin, Shao-Ge Wang, Shen Yin, Wei Shen, Ming-Hui Zhao, Gui-An Huang, Qing-Yuan Sun, Zhao-Jia Ge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
obesity
oocyte
melatonin
DNA methylation
cAMP/PKA/CREB pathway
Online Access:https://elifesciences.org/articles/97507

Internet

https://elifesciences.org/articles/97507

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