MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density

MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density

Abstract Background Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from spontaneous deamination of 5’-methylcytosine. Methods Here, we have inve...

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Bibliographic Details
Main Authors: Christophe Papin, Abdulkhaleg Ibrahim, Jamal S. M. Sabir, Stéphanie Le Gras, Isabelle Stoll, Raed S. Albiheyri, Ali T. Zari, Ahmed Bahieldin, Alfonso Bellacosa, Christian Bronner, Ali Hamiche
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
MBD4
MLH1
Mismatch repair
Cancer
DNA methylation
Online Access:https://doi.org/10.1186/s13046-023-02882-z

Internet

https://doi.org/10.1186/s13046-023-02882-z

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