A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans.

A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans.

Regulation of immunity throughout an organism is critical for host defense. Previous studies in the nematode Caenorhabditis elegans have described an "ON/OFF" immune switch comprised of the antagonistic paralogs PALS-25 and PALS-22, which regulate resistance against intestinal and epiderma...

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Bibliographic Details
Main Authors: Spencer S Gang, Manish Grover, Kirthi C Reddy, Deevya Raman, Ya-Ting Chang, Damian C Ekiert, Michalis Barkoulas, Emily R Troemel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-10-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010314

Internet

https://doi.org/10.1371/journal.pgen.1010314

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