Modulation of IL-6 Expression by KLF4-Mediated Transactivation and PCAF-Mediated Acetylation in Sublytic C5b-9-Induced Rat Glomerular Mesangial Cells

Modulation of IL-6 Expression by KLF4-Mediated Transactivation and PCAF-Mediated Acetylation in Sublytic C5b-9-Induced Rat Glomerular Mesangial Cells

Interleukin-6 (IL-6) overproduction has been considered to contribute to inflammatory damage of glomerular mesangial cells (GMCs) in human mesangial proliferative glomerulonephritis (MsPGN) and its rat model called Thy-1 nephritis (Thy-1N). However, the regulatory mechanisms of IL-6 expression in GM...

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Bibliographic Details
Main Authors: Lu Xia, Yu Liu, Zhiwei Zhang, Yajuan Gong, Tianyi Yu, Dan Zhao, Wen Qiu, Yingwei Wang, Jing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
acetylation
KLF4
PCAF
sublytic C5b-9
IL-6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.779667/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.779667/full

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