Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide

Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide

Mycoplasma fermentans-derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) 2/TLR6. Short proteolytic products including macrophage-activating lipopeptide 2 (MALP2) have been utilized as antitumor immune-enhancing adjuvants. We have chemically synthesi...

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Bibliographic Details
Main Authors: Yohei Takeda, Masahiro Azuma, Kenji Funami, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
antitumor adjuvant
cross-presentation
diacylated lipopeptide
programmed death ligand-1 blockade
toll-like receptor 2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00496/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00496/full

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