Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status

Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status

Abstract Background APOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD), whereas APOE2 confers protection. However, effects of APOE on neurodegeneration in cognitively intact individuals, and how these associations evolve with cognitive decline, are unclear. Furthermore,...

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Bibliographic Details
Main Authors: Emilie T. Reas, Curtis Triebswetter, Sarah J. Banks, Linda K. McEvoy
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
APOE
Diffusion MRI
Brain microstructure
Genetics
Brain aging
Neuroimaging
Online Access:https://doi.org/10.1186/s13195-023-01380-w

Internet

https://doi.org/10.1186/s13195-023-01380-w

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