Deciphering the mechanism of PSORI-CM02 in suppressing keratinocyte proliferation through the mTOR/HK2/glycolysis axis

Deciphering the mechanism of PSORI-CM02 in suppressing keratinocyte proliferation through the mTOR/HK2/glycolysis axis

Hyperplasia of epidermal keratinocytes that depend on glycolysis is a new hallmark of psoriasis pathogenesis. Our previous studies demonstrated that PSORI-CM02 could halt the pathological progression of psoriasis by targeting inflammatory response and angiogenesis, but its effect(s) and mechanism(s)...

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Bibliographic Details
Main Authors: Maojie Wang, Bin Tang, Huanjie Huang, Xiaodong Wu, Hao Deng, Haiming Chen, Liyan Mei, Xiumin Chen, Boudewijn Burgering, Chuanjian Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
psoriasis
PSORI-CM02
proliferating keratinocytes
mammalian target of rapamycin
hexokinase 2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1152347/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1152347/full

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