Dynamics of human protein kinase Aurora A linked to drug selectivity

Dynamics of human protein kinase Aurora A linked to drug selectivity

Protein kinases are major drug targets, but the development of highly-selective inhibitors has been challenging due to the similarity of their active sites. The observation of distinct structural states of the fully-conserved Asp-Phe-Gly (DFG) loop has put the concept of conformational selection for...

Full description

Bibliographic Details
Main Authors: Warintra Pitsawong, Vanessa Buosi, Renee Otten, Roman V Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo AP Pádua, Xavier Meniche, Dorothee Kern
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
protein kinase
drug binding
enzyme kinetics
Online Access:https://elifesciences.org/articles/36656

Internet

https://elifesciences.org/articles/36656

Similar Items