Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic <i>N</i>-Methylated Mini-Hepcidins

Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic <i>N</i>-Methylated Mini-Hepcidins

The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution. Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which reduces both iron absorption in the gut and exp...

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Bibliographic Details
Main Authors: Daniela Goncalves Monteiro, Johannes W. A. van Dijk, Randy Aliyanto, Eileen Fung, Elizabeta Nemeth, Tomas Ganz, Johan Rosengren, Richard J. Clark
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomedicines
Subjects:
hepcidin
ferroportin
cyclic peptides
<i>N</i>-methylation
oral bioavailability
Online Access:https://www.mdpi.com/2227-9059/9/2/164

Internet

https://www.mdpi.com/2227-9059/9/2/164

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